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I believe the billing address on the credit card used to pay for the product must also be a Canadian address. Then again, I don't have an American credit card to test this out...
Easiest way to get an answer is to try to put your credit card's credentials into the system during checkout. If it'll accept a State and Zip Code in lieu of a Province and Postal Code, you should be good. (From the looks of it, Province is a drop-down box, and doesn't give the option to enter a State or Zip Code, so the answer is likely 'no.') 
